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Material Type | Library | Call Number | Item Barcode | Location |
|---|---|---|---|---|
| Book | Searching... Littleton - Reuben Hoar Library | 614.599392 HOL | 39965001837383 | Searching... Unknown |
| Book | Searching... Lowell - Pollard Memorial Library | 616.9792 HOL | 31481004930025 | Searching... Unknown |
| Book | Searching... Westford - J.V. Fletcher Library | 614.5 HOL | 31990004020090 | Searching... Unknown |
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Summary
Summary
Is the end of HIV upon us? Award-winning research scientist and HIV fellow at the Ragon Institute, Nathalia Holt, reveals the science behind the discovery of a functional cure and what it means for the millions affected by HIV and the history of the AIDS pandemic.
Two men, known in medical journals as the Berlin Patients, revealed answers to a functional cure for HIV. Their cures came twelve years apart, the first in 1996 and the second in 2008. Each received his own very different treatment in Berlin, Germany, and each result spurred a new field of investigation, fueling innovative lines of research and sparking hope for the thirty-four million people currently infected with HIV. For the first time, Nathalia Holt, who has participated in some of the most fruitful research in the field, tells the story of how we came to arrive at this astounding and controversial turning point.
Holt explores the two men's stories on a personal level, looking at how their experiences have influenced HIV researchers worldwide--including one very special young family doctor who took the time to look closely at his patients--and how they responded to their medications.
Based on extensive interviews with the patients and their doctors as well as her own in-depth research, this book is an unprecedented look at how scientists pursue their inquiries, the human impact their research has, and what is and is not working in the relationship between Big Pharma and medical care.
Reviews (2)
Publisher's Weekly Review
HIV researcher Holt relates how two HIV-positive men together upended the treatment for the virus that causes AIDS, and helped save countless lives. The two "Berlin patients," as they became anonymously known in medical literature-German-born Christian Hahn and American Timothy Brown-never knew each other. But in this accessible and fascinating account, Holt, a research scientist trained at MIT and Harvard, juggles genetic mysteries, research perils, the agonies of these two reserved and sensitive men diagnosed with what was considered a death sentence, and the dogged doctors who successfully treated them during the later stages of AIDS epidemic-Hahn, in 1996, with early drug therapy and an experimental cancer drug, and Brown, in 2008, with a stem-cell transplant. Holt's narrative brings to light the remarkable early breakthroughs in treating a once fatal condition, but for the Berlin patients, "it wasn't a cure that anyone would want." By themselves, Holt notes, "the Berlin patient cases were anomalies... invitations to fulfill... the promise that HIV can be cured." Their stories, however, are not just memorable for HIV patients, doctors and scientists, but for a society that believes in the importance of their struggles and hopes for their success. Agent: Laurie Abkemeier, DeFiore and Company. (Mar.) (c) Copyright PWxyz, LLC. All rights reserved.
Kirkus Review
A fascinating discourse on how medical science is zeroing in on an HIV vaccine after several anomalous triumphs. With the AIDS epidemic now in its fourth decade, award-winning HIV research scientist Holt believes "we are only just beginning to understand our shared evolution with viruses." Still, she offers increasing hope for a cure by spotlighting the two male "Berlin Patients" and several others, including a child, who chemically bombarded and expunged the HIV virus from their bodies. The author tracks the enduring histories of these menGerman-born Christian Hahn and Timothy Brown, an Americanfrom the detection of their initial viral prodromes to the astonishing depletion of HIV-infected cells from their bodies, prompting clinical trials and controversial research. Holt also profiles HIV specialists Heiko Jessen, Bruce Walker and David Ho as part of a frustrated yet galvanized group of professionals working toward developing new therapies to either counterbalance HIV's onslaught on a vulnerable immune system or, ideally, discover a way to have the virus coexist with its human host. The author includes research that field experts consider "pertinent and exciting," and the result makes for educative, thought-provoking and frequently alarming reading. Textbook descriptions on the intricacies of HIV's tactical viral transmission commingle with a timeline spanning from an era when a seropositive test result equaled a sure death sentence. The author also examines controversial trials of AZT drug therapies, stem cell transplants, and the genetic suppression and inexplicable eradication of the virus from a fortunate few. Holt further supports her subject with graphic illustrations and a well-balanced assortment of interviews and opinions from doctors, genetic scientists and informed researchers, all unified in the global battle to find a cure. An astute AIDS retrospective blended with contemporary updates on aggressive medical strategies.]] Copyright Kirkus Reviews, used with permission.
Table of Contents
| Cast of Characters | p. xi |
| Preface | p. xiii |
| Part I A Doctor, Two Patients, and Some Tests | |
| Chapter 1 The Good Doctor in Denial | p. 3 |
| Chapter 2 A Visit with the Family Doctor | p. 13 |
| Chapter 3 Death Sentence? | p. 21 |
| Part II The Disease, a Drug, and Its Industry | |
| Chapter 4 Viral Trojan Horse | p. 33 |
| Chapter 5 A Weapon from the War on Cancer | p. 43 |
| Chapter 6 The Days of Acting Up | p. 57 |
| Chapter 7 Recognizing a Global Pandemic | p. 65 |
| Chapter 8 From the One Percent | p. 79 |
| Chapter 9 But, Doctor, I Don't Feel Sick | p. 87 |
| Chapter 10 The Delta 32 Mutation | p. 95 |
| Chapter 11 Calling All Elite Controllers | p. 99 |
| Chapter 12 Treatment in Hiding | p. 111 |
| Part III Treating the Berlin Patients | |
| Chapter 13 The Second Diagnosis | p. 119 |
| Chapter 14 The Compassionate Use Exemption | p. 131 |
| Chapter 15 Three Deadly Diseases Move In | p. 135 |
| Chapter 16 The Comfort of Family and Strangers | p. 141 |
| Chapter 17 Timing | p. 147 |
| Chapter 18 Transplanting | p. 153 |
| Chapter 19 "Perhaps We Have Eradicated HIV" | p. 163 |
| Chapter 20 An Unexciting Recovery | p. 175 |
| Part IV The Cure | |
| Chapter 21 Trials | p. 185 |
| Chapter 22 Proof of Principle | p. 199 |
| Chapter 23 The Good Doctor in Court | p. 205 |
| Chapter 24 Not Even Surprising | p. 209 |
| Chapter 25 The Promise Kept | p. 221 |
| Chapter 26 A Child Cured-So What? | p. 241 |
| Chapter 27 Zinc Finger Snap | p. 249 |
| Chapter 28 The Abused, the Respected, the Relentless | p. 261 |
| Notes | p. 273 |
| Timeline | p. 297 |
| Acknowledgments | p. 299 |
| Index | p. 303 |