For San Francisco's newest medical examiner, Dr. Jessie Teska, it was supposed to be a fresh start. A new job in a new city. A way to escape her own dark past. Instead she faces a chilling discovery when an opioid-overdose case contains hints of something more sinister. Jessie's superiors urge her to close the case, but as more bodies land on her autopsy table, she uncovers a constellation of deaths that point to an elaborate plot involving drug dealers and Bitcoin brokers.