The code breaker : Jennifer Doudna, gene editing, and the future of the human race / Walter Isaacson.
Material type: TextPublisher: New York : Simon & Schuster, 2021Edition: First Simon & Schuster hardcover editionDescription: xix, 536 pages : color illustrations ; 25 cmContent type:- text
- still image
- unmediated
- volume
- 9781982115852
Item type | Current library | Collection | Shelving location | Call number | Status | Date due | Barcode | Item holds |
---|---|---|---|---|---|---|---|---|
Adult Book | Phillipsburg Free Public Library | Adult Non-Fiction | New Books | 576.5 ISA | Available | 36748002519975 |
Enhanced descriptions from Syndetics:
A Best Book of 2021 by Bloomberg BusinessWeek , Time , and The Washington Post
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a "compelling" ( The Washington Post ) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn't become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book's author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm...Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an "enthralling detective story" ( Oprah Daily ) that involves the most profound wonders of nature, from the origins of life to the future of our species.
Includes bibliographical references and index.
Introduction. Into the breach -- Part one. The origins of life. Hilo ; The gene ; DNA ; The education of a biochemist ; The human genome ; RNA ; Twists and folds ; Berkeley -- Part two. CRISPR. Clustered repeats ; The Free Speech Movement Café ; Jumping in ; The yogurt makers ; Genentech ; The lab ; Caribou ; Emmanuelle Charpentier ; CRISPR-Cas9 ; Science, 2012 ; Dueling presentations -- Part three. Gene editing. A human tool ; The race ; Feng Zhang ; George Church ; Zhang tackles CRISPR ; Doudna joins the race ; Photo finish ; Doudna's final sprint ; Forming companies ; Mon amie ; The heroes of CRISPR ; Patents -- Part four. CRISPR in action. Therapies ; Biohacking ; DARPA and anti-CRISPR -- Part five. Public scientist. Rules of the road ; Doudna steps in -- Part six. CRISPR babies. He Jiankui ; The Hong Kong summit ; Acceptance -- Part seven. Moral questions. Red lines ; Thought experiments ; Who should decide? ; Doudna's ethical journey -- Part eight. Dispatches from the front. Quebec ; I learn to edit ; Watson revisited ; Doudna pays a visit -- Part nine. Coronavirus. Call to arms ; Testing ; The Berkeley lab ; Mammoth and Sherlock ; Coronavirus tests ; Vaccines ; CRISPR cures ; Cold Spring Harbor virtual ; The Nobel Prize.
"A gripping account of how the pioneering scientist Jennifer Doudna, along with her colleagues and rivals, launched a revolution that will allow us to cure diseases, fend off viruses, and enhance our children"-- Provided by publisher.
Table of contents provided by Syndetics
- Introduction Into the Breach (p. xiii)
- Part 1 The Origins of Life
- Chapter 1 Hilo (p. 3)
- Chapter 2 The Gene (p. 11)
- Chapter 3 DNA (p. 17)
- Chapter 4 The Education of a Biochemist (p. 29)
- Chapter 5 The Human Genome (p. 37)
- Chapter 6 RNA (p. 43)
- Chapter 7 Twists and Folds (p. 51)
- Chapter 8 Berkeley (p. 63)
- Part 2 CRISPR
- Chapter 9 Clustered Repeats (p. 71)
- Chapter 10 The Free Speech Movement Café (p. 79)
- Chapter 11 Jumping In (p. 81)
- Chapter 12 The Yogurt Makers (p. 89)
- Chapter 13 Genentech (p. 97)
- Chapter 14 The Lab (p. 103)
- Chapter 15 Caribou (p. 113)
- Chapter 16 Emmanuelle Charpentier (p. 119)
- Chapter 17 CRISPR-Cas9 (p. 129)
- Chapter 18 Science, 2012 (p. 137)
- Chapter 19 Dueling Presentations (p. 143)
- Part 3 Gene Editing
- Chapter 20 A Human Tool (p. 153)
- Chapter 21 The Race (p. 157)
- Chapter 22 Feng Zhang (p. 161)
- Chapter 23 George Church (p. 169)
- Chapter 24 Zhang Tackles CRISPR (p. 175)
- Chapter 25 Doudna Joins the Race (p. 187)
- Chapter 26 Photo Finish (p. 191)
- Chapter 27 Doudna's Final Sprint (p. 197)
- Chapter 28 Forming Companies (p. 203)
- Chapter 29 Mon Amie (p. 215)
- Chapter 30 The Heroes of CRISPR (p. 223)
- Chapter 31 Patents (p. 231)
- Part 4 CRISPR in Action
- Chapter 32 Therapies (p. 245)
- Chapter 33 Biohacking (p. 253)
- Chapter 34 DARPA and Anti-CRISPR (p. 259)
- Part 5 Public Scientist
- Chapter 35 Rules of the Road (p. 267)
- Chapter 36 Doudna Steps In (p. 283)
- Part 6 CRISPR Babies
- Chapter 37 He Jiankui (p. 299)
- Chapter 38 The Hong Kong Summit (p. 315)
- Chapter 39 Acceptance (p. 325)
- Part 7 The Moral Questions
- Chapter 40 Red Lines (p. 335)
- Chapter 41 Thought Experiments (p. 341)
- Chapter 42 Who Should Decide? (p. 355)
- Chapter 43 Doudna's Ethical Journey (p. 367)
- Part 8 Dispatches from the Front
- Chapter 44 Quebec (p. 373)
- Chapter 45 I Learn to Edit (p. 379)
- Chapter 46 Watson Revisited (p. 385)
- Chapter 47 Doudna Pays a Visit (p. 395)
- Part 9 Coronavirus
- Chapter 48 Call to Arms (p. 401)
- Chapter 49 Testing (p. 407)
- Chapter 50 The Berkeley Lab (p. 413)
- Chapter 51 Mammoth and Sherlock (p. 421)
- Chapter 52 Coronavirus Tests (p. 427)
- Chapter 53 Vaccines (p. 435)
- Chapter 54 CRISPR Cures (p. 449)
- Chapter 55 Cold Spring Harbor Virtual (p. 459)
- Chapter 56 The Nobel Prize (p. 469)
- Epilogue (p. 477)
- Acknowledgments (p. 483)
- Notes (p. 487)
- Index (p. 517)
- Image Credits (p. 535)